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Molecular structure and dynamics

Structure determination of compatible solutes

Compatible solutes are small organic solutes, accumulating in the cytoplasm of halotolerant or halophilic microorganisms as a response to salinity or thermal stress.

Research effort at ITQB in this area, using NMR correlation spectroscopy has revealed a number of new organic solutes highly restricted to (hyper)thermophiles.

Pedro Lamosa et al. (2015) Extremophiles. doi: 10.1007/s00792-014-0723-0

 

Structure determination of EPS repeating unit

Many lactic acid bacteria (LAB) produce exopolysaccharides (EPS). These are economically important molecules conferring most of the organoleptic properties of many fermented food products and may confer beneļ¬cial health effects.  In order to engineer the production of EPSs with improved desired properties we need a deep understanding of how the structure of EPSs relate to a functional effect. Using high resolution NMR we succeeded in determining the structure of many EPSs at CERMAX

Pedro Lamosa et al. (Ongoing work)